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The pathogenesis begins with chronic endothelial injury from risk factors like hypertension, diabetes mellitus, and dyslipidemia, all present in this patient

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However, the precise molecular mechanisms responsible for the progress of this neoplasm in humans are still poorly understood [54]

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I personally have two copies of the MTHFR mutation and am alive and well (with some interventions), while others I have seen have just one copy of a mutated gene, and a lot of symptoms