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Mechanistic studies have demonstrated that 5(S),15(S)-DiHETE-mediated ferroptosis signalling facilitates the degradation of hypoxia-inducible factor-1 (HIF1)

drafting the article and critically revising the intellectual content

its deficiency compromises mucosal anti-inflammatory and reparative functions (Zhu et al., 2022)

Additionally, abnormalities in fatty acid -oxidation (FAO) and amino acid metabolism can lead to the buildup of lipids and uremic toxins in the kidney, which can contribute to renal cell damage and apoptosis [4, 8]

To build the final regulons, we merge the inferred target genes of each TF-module that show enrichment of any motif of the given TF

In the cells, a decrease was observed in mRNA levels of Bmal1, Clock, Per2 , and Ror , as well as in the level of antioxidant genes, namely Cat , glutathione peroxidase ( Gpx ), glutathione S transferase ( Gst ) and superoxide dismutase ( Sod )