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Conclusion This review elucidated the significance of the metabolism-inflammation-oxidative stress axis in the occurrence and development of OA, and also dialectically discussed the mechanisms and clinical benefits of beneficial nutrients in the treatment of OA
These pathways have been proposed to be of central importance for matching of oxygen demand to its delivery in the microcirculation of the skeletal muscle during hypoxic work (53)
Researchers primarily examine its effects on vital organs such as the liver, kidneys, and heart
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The crucial role of IGF-I in the development and function of Leydig cells was obtained from studies in IGF-I knockout mice[124]
