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Among women whose dietary intake of vitamin B-12 was less than the Indian RDA during pregnancy (1.2 g/d) in the first trimester, the frequency of IUGR was 17 of 61 (28%) in the vitamin B-12 group and 17 of 50 (34%) in the placebo group ( P = 0.14 by 2 test)

This disruption results in ineffective erythropoiesis and intramedullary hemolysis