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49 Furthermore, elevated ROS induce aberrant mitochondrial dynamics, characterized by excessive mitochondrial fission and reduced fusion protein expression, ultimately resulting in mitochondrial fragmentation and exacerbation of mitochondrial dysfunction

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In a large, rigorous review of over 50 studies involving more than one million patients, metformin use in patients with type 2 diabetes was associated with a 35% reduction in risk of death from cancer, and a 27% reduction in risk of any cancer (Franciosi 2013)