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Previous studies [9,10] have demonstrated that oral folinic acid, oral trimethylglycine, and subcutaneous injections of methyl Vitamin B12 were able to greatly improve methylation, glutathione, and oxidative stress, similar to the results here

Peng W, Qian Y, Qi X (2023) Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin

Hey et al., 2023)

Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training

Interestingly, ursodeoxycholic acid, the only treatment approved by the Food and Drug Administration for the treatment of primary biliary cirrhosis, a chronic cholestatic disorder, was shown to prevent the fall in GCL expression during chronic cholestasis (Serviddio et al., 2004) and increase GCL expression in cultured rat hepatocytes (Mitsuyoshi et al., 1999)

1 The initiation, also called priming, corresponds to the activation of the immediate-early response genes by pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF ) 2 and interleulin-6 (IL-6) 3 that induces the G0/G1 transition of quiescent hepatocytes