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Proteolytic digestions of Mpro revealed Cys300 as a primary target of glutathionylation, and experiments using a C300S Mpro mutant revealed that Cys300 is required for inhibition of activity upon Mpro glutathionylation

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Magnesium, zinc and molybdenum are integral to DNA repair and enzyme activity

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These complex structures provide the first information regarding the location of the ascorbate and GSH binding sites and their interacting residues