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When Nrf2 responses are inadequate, lipid peroxides can trigger inflammation through the nuclear factor kappa B (NF-B) pathway ( NF-B functions as a principal modulator of inflammatory processes (Nowak and Relja, 2020)

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Coffee contains powerful antioxidants like polyphenols, hydroxycinnamates, and chlorogenic acid ( Though studies show that hot coffee contains more total antioxidants than cold brew varieties, the latter packs some very potent antioxidants, such as caffeoylquinic acid (CQA) ( Summary Though cold brew coffee contains fewer total antioxidants than hot coffee, its full of compounds that have high antioxidant activity

One randomized placebo-controlled trial that examined metabolic syndrome patients for the effect of bacterial transplantation on the treatment of the disease established changes in the structure of the intestinal flora of the two groups of patients 2 weeks after transplantation but no alterations in the ability to produce TMAO ( FMT is potentially an effective measure to reduce the level of circulating TMAO and the risk of AS