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SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1
Longitudinal analyses revealed increased abundance of certain species/strains/pathways/metabolites before CD onset, previously associated with autoimmune and inflammatory conditions, while others decreased before CD onset and have anti-inflammatory effects [52]
These changes may weaken the efficacy of anti-CTLA-4 therapy (Coutzac et al., 2020)
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Propionate mitochondrial toxicity in liver and skeletal muscle: acyl CoA levels
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