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The NPs could be of various shapes, sizes, and origins, i.e., metallic or organic, solid or liquid, and carbon-based

J Appl Physiol 54(1):208214 Chang HH, Chen CS, Lin JY (2009) High dose vitamin C supplementation increases the Th1/Th2 cytokine secretion ratio, but decreases eosinophilic infiltration in bronchoalveolar lavage fluid of ovalbumin-sensitized and challenged mice

As a result the clinicians use arbitrary empirical dosage schedules which lead to inconsistent results

doi: 10.1111/phpp.12315

Functional and molecular defects of pancreatic islets in human type 2 diabetes

Although there is no real downside to consuming too much of vitamin C (except rarely maybe an irritated stomach or diarrhea)