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Alzheimers Dement 2022

Neuroprotection Research Investigations in brain injury and neuroinflammation models demonstrated: Enhanced memory formation and consolidation when fused with blood-brain barrier-penetrating peptides Amelioration of memory deficits induced by amyloid-beta or lipopolysaccharide Significant downregulation of hippocampal pro-inflammatory cytokines Potential therapeutic relevance for age-related cognitive decline Critical Research Limitation: Despite extensive animal research spanning metabolic disorders, aging, and physical performance, MOTS-c has NO completed peer-reviewed human clinical trials published in scientific literature

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Nature 510:109114 Morrison JH, Lewis DA, Campbell MJ et al (1987) A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimers disease