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Short-chain polyunsaturated fatty acids, PUFAs, such as linolenic acid (LA, omega-6 PUFA) and -linolenic acid (ALA, omega-3 PUFA), are primarily found in plant seeds and are considered essential fatty acids

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Data availability The experimental data used to support the findings of this study are available from the corresponding author upon request

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Pharmacological inhibition of vanin-1 using RR6 also did not significantly affect insulin sensitivity or fasting blood glucose levels 42,43

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Creatine metabolism exemplifies interorgan coordination [92]

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However, large molecules, hydrophilic compounds, and many therapeutic agents, such as antibodydrug conjugate (ADC), are excluded, limiting the ability of systemic treatment to reach the brain

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