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In a study by Delgado and colleagues [49], VIP was shown to effectively limit harmful A-induced microglia activation and the subsequent release of neurotoxins, such as tumor necrosis factor (TNF)-, interleukin (IL)-1, and nitric oxide (NO)

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This growing body of evidence highlights how microglial cell behavior can influence neuronal death and neurogenesis (Hu et al., 2015