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To date, the score has been implemented with considerable variation in literature and initial positive evaluations were not reproduced in subsequent studies

In fact, lysosomal damage not only disrupts intracellular clearance but also results in the leakage of multiple contents, which pose great threats to the cell by triggering cell death pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis

This case series aims to raise awareness of this rare condition, its importance in relation to patient consent and provides a simplified management approach based on our experience

Linearity has been shown over the reduced concentration range 0.030.5 mg/L whereas a multiplicative model (lnln transformation) had to be used to describe the full range of concentrations 0.0320 mg/L