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The persistence of pain, impairment of cognitive function, and negative impact on the psychological state have caused a detrimental effect on the patients' quality of life

Circulation 90 : 21262146 Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD and Lusis AJ (1995) Atherosclerosis: basic mechanisms
Delving deeper, there is a subset of research suggesting an intriguing link: heightened IL-22 serum levels and adiponectin are positively correlated with the PASI metrics

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Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy