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Because tocotrienol functions as signaling molecule in addition to providing antioxidant activity (39), the observed increase in oxidative DNA damage with TRF treatment may be the result of signal transduction preceding the initiation of cell apoptosis (40) that stimulated cellular regeneration and thus restored the lifespan of C

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438 Notably, compared with systemic application, topical administration of sodium butyrate modulates IL-10 and Foxp3 expression, diminishing imiquimod-induced skin thickening, scaling, and inflammation

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