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In the presence of ROS, TXNIP is disassociated from Trx and binds to NLRP3

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However, it should be taken into account that although the difference in the pKa values of the two acidic groups of 4-hydroxythalidomide is sufficient to ensure selective alkylation of the phenolic group, a reaction may still occur in the imide nitrogen zone given its adequately acidity

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Additionally, urban residents were more prone to POAG than their rural counterparts (15)

DSS mice were intraperitoneally injected with miR-125a-5p agomir or agomir NC, and miR-125a-5p expression in colon tissue was tested (Fig