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Chronic stress influences the onset, progression, and mortality of cancers by modulating hallmarks of cancer, including immune evasion, angiogenesis, sustained proliferation, metastasis, and metabolic reprogramming (46)

Age is a key risk factor: incidence rises after age 54, peaking at 7584 years (1524 cases/100,000 population), with a median diagnosis age of 64 [45]

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The anti-alzhemeric property of phytochemicals has been attributed to them by either of the following mechanisms: Antioxidative and radical scavenging activities Acetylcholiesterase inhibition Anti-inflammatory activity Modulation of antioxidant machinery Plants with traditional knowledge of antioxidant and anti-alzhemeric activity have been studied [136]