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While methylation is dependent on B vitamins and minerals, de-methylation is dependent on vitamin C , which is a cofactor for a group of recently discovered Ten-Eleven Methylcytosine Dioxygenase Translocation de-methylation enzymes (or TET for short) (Source 5)

Last reviewed: June 11, 2026 Last updated: June 11, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Combination Stacks COMMUNITY-SOURCED INFORMATION The dosing information below is drawn from community reports, forums, and anecdotal sources not clinical trials

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