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However, the lower extent of ROS keeps the cell in a reduced state and can be employed as a second messenger participating in cell division and differentiation, stem cell maintenance, organogenesis as well as maintenance of stress responses [45]

Although anti-cancer therapy targeting metabolism has achieved some gratifying results, it is still currently believed that this field has the following shortcomings for possible future breakthroughs: 1) The side effects of such drugs limit their clinical effects as the optimal dose window is hard to be determined

[DOI] [PubMed] [Google Scholar] [114].Huang H, Manton KG

[DOI] [PMC free article] [PubMed] [Google Scholar] 256.Mirault ME

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it is not thought to have any other previously unknown risks or long-term effects