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This leads to the indirect activation of v-raf murine sarcoma viral oncogene homolog B1 (RAF) kinases, which can subsequently activate the MAPK effector kinase MEK and finally MAPK, which can then translocate to the nucleus to activate transcription factors responsible for regulating a large number of genes

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The dopaminergic system reaches a new equilibrium

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It was also fund that dopamine receptor 2 agonist suppresses appetite in both wild-type and ghrelin-null mice, but not in GHS-R null mice 28