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10.1074/jbc.M404596200 167 PengJ.StevensonF

[ref] Dextromethorphan: Commonly found in cough syrups, dextromethorphan is a low-affinity uncompetitive NMDAR antagonist

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However, reduced levels of NRX disrupt the interaction between KLHL12 and Dvl, preventing Dvl degradation and preserving the pool of Dvl necessary for sustaining Wnt/-catenin signaling

In fact, the increased glial fibrillary acidic protein (GFAP) immunoreactivity, inhibition of replication/differentiation and induction of oxidative stress in C6 glioma cells, and of glial development in vivo , were reported (Garcia et al., 2001, 2002

It involves the screening of small and less complex compounds, generally with molecular weight (MW) 1) chemotypes bound, while sites S10S16 bound to a single fragment each