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As it has been reported, the prevalence of melasma is much higher in the Middle East and South East Asians, Hispanic Americans, Mediterranean Africans, and also Brazilian (Majid and Aleem, 2021)

354 In contrast, familial neurodegenerative disorders, such as inherited PD, often benefit from sustained autophagy activation as a result of persistent proteotoxic stress, whereas sporadic cases may show variable responses depending on the metabolic state and disease progression

Author contributions HL and ZW contributed to the initial concept and perspectives

Gomez M

The function of lncRNAs in the pathogenesis of HT is still under investigation, but it has been shown that they regulate gene expression through interactions with transcription factors and chromatin

104.Sadeque M.S.B., Chowdhury H.K., Rafique M., Durmu M.A., Ahmed M.K., Hasan M.M., Erba A., Sarpkaya ., Inci F., Ordu M