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The mechanisms underlying drug resistance are complex, and can include DNA damage repair, genetic mutation, changes in signaling pathways, abnormal transmembrane transport, immune escape, epithelial-mesenchymal transition, changes in the tumor microenvironment (TME), epigenetic changes, autophagy, and cell cycle disorders [6, 12,13,14]

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Short course duration sofosburiv/velpatasvir is inferior to standard duration therapy in the treatment of recently acquired HCV infection: results from REACT study [abstract LP2]

The subsequent hydrolysis of the pyrophosphate renders the reaction irreversible