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Abstract Background Fatigue of unknown origin is a hallmark symptom in chronic fatigue syndrome (CFS) and is also found in 20% of hypothyroidism patients despite appropriate levothyroxine treatment
The most commonly reported adverse reaction (adverse event assessed as causally related by investigator and all grades) was nausea (7%)
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doi: 10.1016/S0272-6386(03)00113-6
Thyrotropin-axis adaptation in aging and chronic disease
