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This dissociation between the regulation of activation (rise time) and inactivation (desensitization) suggests that Neto proteins primarily stabilize the open state rather than the initial opening transition
its fine-tuning within an already efficient system
But the weight gain is not a direct result of the deficiency but rather an indirect result
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Targeting HDAC6 and Sirt2 has been proposed as a potential neuroprotective strategy, as these enzymes regulate cellular stress responses and cytoskeletal stability in neurons
