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Table 2 Summary of interventions and outcomes on muscle protein synthesis and anabolic responses in older adults following BCAAs and exercise interventions

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Although in cognitively healthy individuals differences in BBB uptake have been observed with APOE genotypes as early as in individuals in their 30s (Yassine et al., 2017) in mice older ages may be required for such disturbances to occur (Alata et al., 2015)