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A steady drop in NAD+ production and a faster rate of NAD+ depletion, both of which reduce the amount your cells can actually use

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Liver cirrhosis represents a post-injury liver repair response wherein hepatic stellate cell (HSC) activation plays a pivotal role, alongside liver sinusoidal endothelial cells (LSECs) regulation, cytokine release, and fibrous scar tissue deposition (Kisseleva and Brenner, 2021)

10.1021/jacs.7b02432