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If mosquito populations with heterogeneous traits are systematically exposed to sublethal levels of ivermectin, this may result in the selection of genes or genetic loci in the population that increase their chances of surviving exposure to ivermectin

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These changes are detectable even in the early stages, suggesting that ferroptosis may serve as an initiating molecular event

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These include decreased sperm count, motility and morphology in males, as well as adverse pregnancy outcomes in females, such as maternal thyroid dysfunction and congenital hypothyroidism