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Parent-Observed Clues: When Oxidative Stress May Be Part of the Pattern Fatigue that seems out of proportion to activity Slow or incomplete recovery after ordinary childhood illness Heat intolerance or unusual sensitivity to exertion Low muscle tone Sensory sensitivity that appears to worsen during illness or stress Behavior or regulation changes that track with fatigue or being unwell These are clues, not diagnostic signs

Vazquez-Meza H, Vilchis-Landeros MM, Vazquez-Carrada M, Uribe-Ramirez D, Matuz-Mares D

Hydrogen peroxide is a cell-permeant molecule that operates both intra- and extra-cellularly and can be decomposed by traces of iron to damaging hydroxyl radicals (Fenton reaction)

Redox-responsive fluorescent probes with different design strategies

Stokes, P