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Depletion of GSH as a consequence of acetaminophen toxicity to the liver has attracted the most attention in the medical scientific community, as it can frequently be fatal or require a liver transplant or emergency treatment to prevent liver failure (the liver is the organ with the greatest concentration of GSH)

Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose

Enhanced stability, antioxidant capacity and in vivo anti-inflammatory efficacy of glutathione and quercetin via nanoemulsion formulation

doi: 10.1172/JCI152345 [DOI] [PMC free article] [PubMed] [Google Scholar] 148

Another protein of interest, SLC25A11, was also found to be upregulated in the PBMCs of ME/CFS patients compared with controls

To reflect the fact that NAPstars measure the NADPH/NADP + ratio, rather than the NADPH concentration, from now on we report K ratios ( K r(NADPH/NADP+) ) for every NAPstar instead of K d(NADPH) (Fig