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[ref][ref][ref][ref] Brain atrophy: High homocysteine is associated with brain atrophy and cognitive decline in aging

doi: 10.1016/j.cell.2019.06.003

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The global societal burden is equally significant, with total direct and indirect costs estimated to exceed $112 billion USD annually by 2023 (Ola et al., 2022

Therefore, apart from proving efficacy, future clinical trials must generate robust biomarkers for safety and durability that allow personalized checkpoint immunomodulation

(Source) Early evaluation improves symptom control, preserves fertility, and reduces the emotional burden of recurring pain