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Differential cellular effects in the toxicity of haloalkene and haloalkene cysteine conjugates to rabbit renal proximal tubules

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We examine the history of attempts to develop oral GLP-1 therapies, the structural biology of non-peptide GLP-1 receptor activation, the pharmacokinetic advantages of orforglipron's small-molecule architecture, the complete Phase 2 and Phase 3 clinical dataset, comparisons with both oral and injectable GLP-1 agonists, the manufacturing and cost implications of small-molecule production, the safety profile across all completed trials, and the regulatory pathway and timeline for approval

Isobaric labeling was performed using the 10-plex TMT system (Thermo) 15

Biochemical and biophysical research communications, 2025, 742: Article 151060

Acknowledgements This work was supported by the National Key Research and Development Project of China (2023YFC3402100), the National Natural Science Foundation of China (81821002 and 82130082, 82341004), 135 project for disciplines of excellence, West China Hospital, Sichuan University (ZYGD22007)