caffeine depletes glutathione Can I Drink Coffee with Glutathione? Understanding the Interactions and Maximizing Benefits Glutathione IV Detox: Is It

doi: 10.2337/dc13-2278

Vollenweider et al., 2010)

It may also be responsible for toxicity and liver failure seen at lower doses (Amar 2007)

However, no large-scale human clinical trials have been completed, so long-term safety data in humans remains limited

Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration

AOD-9604 Dosing Protocols for Metabolic Support Proper dosing of AOD-9604 is essential for optimizing metabolic benefits while maintaining safety and tolerability