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Supplementary material The Supplementary Material for this article can be found online at: References 1 AbdulmalikA

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Savastano, S., Di Somma, C., Barrea, L

9 April 2019

As a widely used healthcare guideline for opened multi-dose vials, vials are commonly dated and discarded within 28 days after first puncture unless the manufacturer states a different timeframe

Mutations often result in loss of normal p53 function, although gain-of-function mutations are also observed, leading to generally more aggressive cancer phenotypes