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Conventional HSP90 inhibitors and PROTACs have shown limited clinical success, largely owing to systemic toxicity, suboptimal pharmacokinetic profiles, and insufficient degradation efficiency

doi: 10.1038/s41586-020-03129-z [DOI] [PMC free article] [PubMed] [Google Scholar] 10

Downs BM, Thursby SJ, Cope L

Soares et al., 2019

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conducted research on the anti-carcinogenic effects of AX and other carotenoids [33,34]
