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Also, p62 recruited to the damaged mitochondria ubiquitinates Mcl-1, leading to its degradation and activation of apoptosis [305]

Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy

Reduced p27Kip-1 levels, often due to overexpression of the F-box protein Skp2, are associated with tumor progression and poor prognosis in various cancers

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283 While some proteins accept their cofactors after folding into their native conformation, others incorporate their cofactors during the folding process and diverge in the folding kinetics, structure, and stability of their apo- and holoprotein forms

GC1 KO reverses KRAS mutant-induced immunosuppression by reducing myeloid-derived suppressor cell (MDSC) recruitment and enhancing CD8+ T-cell infiltration [114]