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Findlay VJ

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Abbreviations AOR: Adjusted odds ratio BI: Bartel index CE: Cardioembolic stroke CI: 95% Coincidence interval GSH: Glutathione GSNO: Nitrosoglutathione HHcy: Hyperhomocysteinemia LA: Large-artery atherosclerosis MR: Magnetic resonance MRI: Magnetic resonance imaging mRs: Modified Rankin scale NIHSS: National Institutes of Health Stroke Scale OR: Unadjusted odds ratio rGSH: Reduced glutathione RR: Risk relative risk tGSH: Total glutathione TOAST: Trial of ORG 10172 in acute stroke treatment References Kolominsky-Rabas PL, Weber M, Gefeller O, et al

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One of the key pathways involved is the activation of the NLRP3 inflammasome by mitochondrial reactive oxygen species (mtROS)

The restoration of biomechanical properties demonstrated in animal ligament models suggests potential for improved outcomes compared to rest and splinting alone