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In addition, brain microglia-derived cytokines (IL-1, IL-6, IL-12, and TNF) become elevated and appear to facilitate disease progression [46]

Hydrogen peroxide (H 2 O 2 ) is produced during Hb autoxidation by the spontaneous and enzyme driven dismutation of superoxide (Equation 2)

The main cause of vitamin B12 or folate deficiency is poor dietary intake of the vitamin (not taking adequate levels of the vitamins from food)

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Its primary job is to combat oxidative stress by neutralizing free radicalsthose unstable molecules that damage cells, proteins, and DNA, contributing to aging and disease

Nonetheless, the impact of these antioxidant supplements on the OS profile, antioxidant defenses and metabolism of stored erythrocytes has not been explored