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The next important group of H 2 S prodrugs, some of which entered the clinical phase, includes H 2 S-releasing modifications of many clinically used drugs with the well-known ATB-346 which is a H 2 S-releasing derivative of naproxen [170,171] (Figure 12)

10.1111/1440-1681.13271 45 ChenX.FengL.LiS.LongD.ShanJ.LiY
Mitochondrial or nuclear Gpx4 deletion in mice causes male infertility without impairing embryogenesis or postnatal development [58, 59]

Ferroptosis triggered by dihydroartemisinin facilitates chlorin e6 induced photodynamic therapy against lung cancerthrough inhibiting GPX4 and enhancing ROS

Canalis E, Yu J, Schilling L, Yee SP, Zanotti S

Neurochem Res 27: 113120, 2002
