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This contrasts with GLP-1-based weight loss, where approximately 40% of total weight lost is lean tissue
Its application to deeper knee structures such as the joint capsule, ligaments, or cartilage in human patients remains largely theoretical at this stage
Future studies should incorporate human iPS cell-derived astrocyte models, precision delivery platforms and multimodal biomarkers to bridge these gaps and accelerate astrocyte-based therapies from mechanistic insight to clinical practice
As osteoarthritis is primarily caused by inflammation of the musculoskeletal system which worsens due to oxidative stress, clinical studies turned their focus towards the research of the substances that could prevent or attenuate that
In older adults, secretion of hydrochloric acid in the stomach is reduced significantly, which can lead to poor absorption of vitamin B12
Moreover, in cardiac fibroblasts, luteolin is also anti-fibrotic through the NO-cGMP signaling pathway [242, 243]
