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This limits the effectiveness of simple topical application

182 In the second study, some patients had been followed for more than five years, with continued reports of efficacy as long as the medication was maintained

Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features

LOR, loricrin

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Clinical trial protocols treated missed doses this way: if a scheduled weekly dose is missed and 5 or fewer days have passed, the dose can be taken when remembered