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Description
In fact, in myopathy, pathophysiological events lead to fiber necrosis, apoptosis, autophagy elevation in reactive oxygen species, mitochondrial dysfunction, increases in protein catabolism and degradation, and rise in intracellular calcium content [43], and all these elements may represent sites of attack for creatine


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Nardin RA, Johns DR: Mitochondrial dysfunction and neuromuscular disease

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