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Although many studies provide evidence for the observed link between the usage of metformin and deficiency of vitamin B12, there remains uncertainty regarding whether metformin directly causes anemia and, if so, whether this is primarily driven by deficiency of vitamin B12 in individuals with type 2 diabetes mellitus (T2DM) undergoing metformin therapy [48,49]

Loop diuretics (e.g., furosemide): Enhance renal potassium excretion in patients with preserved kidney function

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