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Int J Biol Macromol 190:607

After severe cerebral ischemia, Glu/Gln as well as GABA/Gln ratios extensively dropped in early reperfusion (3 h) and gradually increased in 72 h reperfusion time, however, only the Glu/Gln ratio recovered to the level of controls
Given that IR can induce ferroptosis in various tissue cells
doi: 10.1016/S0021-9258(20)80702-9

This process, while seemingly paradoxical, can lead to significant tissue damage and cell death, often exceeding the initial injury caused by ischemia alone[323, 324]

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