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FIGURE 3 However, the limitation of passive targeting is that its targeting is relatively weak, and it is greatly affected by tumor heterogeneity and individual differences ( 2.2.2 Active targeting Active targeting, by contrast, modifies specific targeting molecules (such as antibodies, peptides, aptamers, etc.) on the surface of the nanocarriers so that they can accurately recognize and bind to specific antigens or receptors on the surface of tumor cells, thus achieving efficient drug delivery