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They certainly expected this criteria to be immutable though

The further roles of NNMT in regulating glucose metabolism and the related mechanisms are mainly from Kraus et al

, Gomes, A

By making maintenance therapy fit each persons needs, doctors can help keep Vitamin B12 levels high
The NHS treatment page lays it out clearly: Loading phase (no neurological symptoms): 1mg every other day for two weeks, or until symptoms stop improving