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Wright and Dyson, 1999

A study review conducted in 2019 found that animal studies support many beneficial effects of vitamin B12, including the inhibition of cyclooxygenase enzymes and other pain-signaling pathways
It is understood that a permanently increased sugar level could damage the nerves, however a B12 deficiency caused by diabetes drugs is also today a proven cause (55)

This can reduce the margin of error when measuring

Ann Nutr Metab

You may also want TMG / Betaine TMG (Trimethylglycine or Betaine) may be helpful for some