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Subsequently, Cooper and Meister, 1974, Cooper and Meister, 1981 discovered that rat tissues contain at least two glutamine transaminases, a kidney type named glutamine transaminase K (GTK, highest specific activity in the kidney but well represented in other tissues), and a liver type named glutamine transaminase L (GTL, predominantly in the liver, with lower activity in other tissues)

Among these dominant repurposed drug candidates, various avenues are being explored

Understanding how these chaperone systems are coordinated and how their protective capacity declines with age and disease will be essential for developing effective proteostasis-based therapies for NDDs

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Menendez, A

However, this is an intermediate process, not the final result, and the mechanism behind the final cell death is still unclear