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So let's start there

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& Deisseroth, K
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

the vitamin D receptorCREBTrkBBDNF mechanism

Until further investigations are done on liver stores and humans where this process is broken we can only go on our symptoms and what works for each individual to relieve these symptoms and to heal as much as possible